Thermo Fisher Scientific TAB1 Polyclonal Antibody
TAB1 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat에 반응하며, 고순도 Affinity chromatography로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TAB1 (Accession Q15750), corresponding to amino acid residues P412–F462 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900635 |
Product Specific Information
Antibody detects endogenous levels of total TAB1.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminal portion acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein mediates between TGF beta receptors and TAK1. TAB1 can also interact with and activate MAPK14/p38alpha, representing an alternative activation pathway contributing to MAPK14 biological responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-116001_TAB1_Q15750-1_Rabbit_PDP.jpeg, PA5-116001_TAB1_Q15750-1_Rabbit.svg)
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