Thermo Fisher Scientific HECW1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HECW1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HECW1,uniProtId:Q76N89-1,ncbiNodeId:9606,antigenRange:356-481,antigenLength:1606,antigenImageFileName:PA5-52457_HECW1_Q76N89-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52457_HECW1_Q76N89-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642373

Product Specific Information

Immunogen sequence: STEPESAQIQ DSPMNNLMES GSGEPRSEAP ESSESWKPEQ LGEGSVPDGP GNQSIELSRP AEEAAVITEA GDQGMVSVGP EGAGELLAQV QKDIQPAPSA EELAEQLDLG EEASALLLED GEAPAS

Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 44%.

Target Information

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.