Thermo Fisher Scientific CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), APC, eBioscience
인간 및 비인간 영장류 CD185(CXCR5)를 인식하는 MU5UBEE 단클론 항체로, APC 형광체가 결합되어 있습니다. 유세포분석(Flow Cytometry)에 적합하며, B세포 및 여포성 보조 T세포 연구에 활용됩니다. 4°C 암소 보관, 동결 금지.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.125 µg)/test
- View 10 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate, Rhesus monkey |
| Published Species | Human, Rhesus monkey |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MU5UBEE |
| Immunogen | N-terminal extracellular domain of CXCR5 |
| Conjugate | APC (Allophycocyanin) |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573296 |
Available Formats
- Unconjugated
- Alexa Fluor 532, 700
- Biotin
- Brilliant UV 395, 615, 737, 805
- Brilliant Violet 421, 480, 605, 786
- eFluor 450
- FITC
- NovaFluor Blue, Red, UV, Violet, Yellow series
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436, 600, 645, 702
- Request custom conjugation
Product Specific Information
The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185 (CXCR5, also known as BLR1).
CD185 is a seven-transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. It is expressed on B cells, CD4⁺ T cells (excluding Th1 and Th2), and subsets of memory (CD45RO⁺) T cells.
In tonsil tissue, CD185⁺ cells co-express CD45RO, CD69, and ICOS, and play a role in B cell help and antibody production.
CXCR5 is critical for lymphocyte trafficking, particularly T cell migration to B cell follicles in response to CXCL13, serving as a key marker of follicular helper T cells.
- Cross-reactivity: Rhesus macaque
- Application Reported: Flow cytometric analysis
- Application Tested: Pre-titrated, tested on normal human peripheral blood cells
- Recommended Use: 5 µL (0.125 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test)
- Excitation: 633–647 nm
- Emission: 660 nm
- Laser: Red laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CXCR5 (C-X-C Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), is a G protein-coupled receptor for chemokine BLC. It is expressed in Burkitt’s lymphoma and lymphoid tissues such as lymph node follicles and spleen.
CXCR5 plays a crucial role in B cell migration and lymphocyte trafficking. Expression has been reported in human blood, salivary gland, and multiple animal tissues including lymph nodes, spleen, and tonsil.
As a member of the GPCR family, CXCR5 shares the seven-transmembrane domain structure and participates in signal transduction via G-proteins. GPCRs are major drug targets, with notable examples including Zyprexa and Claritin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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