Thermo Fisher Scientific RUVBL2 Polyclonal Antibody
RUVBL2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제된 액상 항체이며, PBS/glycerol buffer에 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RUVBL2 (Accession Q9Y230), corresponding to amino acid residues M178–P228 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851917 |
Product Specific Information
This antibody detects endogenous levels of total RUVBL2.
Target Information
RUVBL2 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′ to 3′) activity. It is a component of the NuA4 histone acetyltransferase complex, which is involved in transcriptional activation of specific genes by acetylating nucleosomal histones H4 and H2A. This modification can alter nucleosome-DNA interactions and facilitate recruitment of transcriptional regulators.
The NuA4 complex plays roles in:
- Oncogene and proto-oncogene mediated growth induction
- Tumor suppressor-mediated growth arrest and replicative senescence
- Apoptosis and DNA repair
RUVBL2, in association with RUVBL1 and EP400, contributes to the ATPase and helicase activities of the NuA4 complex. It is essential for oncogenic transformation by MYC and modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. RUVBL2 may also inhibit the transcriptional activity of ATF2.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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