Thermo Fisher Scientific IGF2 Polyclonal Antibody
IGF2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ICC, ELISA에 사용 가능하며 고순도 Affinity Chromatography로 정제되었습니다. 안정적인 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 25–180 of human IGF2 (NP_000603.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 7.16 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914354 |
Product Specific Information
- Positive test controls: HepG2, SW480, Mouse brain
- Subcellular location: Secreted
Immunogen sequence:
AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSERDV STPPTVLPDN FPRYPVGKFF QYDTWKQSTQ RLRRGLPALL RARRGHVLAK ELEAFREAKR HRPLIALPTQ DPAHGGAPPE MASNRK
Target Information
The insulin-like growth factors (IGFs) are mitogenic polypeptides that promote proliferation and survival of various cell types, including muscle, bone, and cartilage. IGFs are mainly produced by the liver, though other tissues also synthesize them at specific times. They belong to the insulin gene family, sharing structural and functional similarities with insulin but exhibiting stronger growth-promoting activity.
IGF-II expression is regulated by placental lactogen, while IGF-I is regulated by growth hormone. Both signal through the IGF-I receptor (IGF-IR), but IGF-II can also interact with the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursors containing N- and C-terminal propeptides.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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