Thermo Fisher Scientific ING3 Polyclonal Antibody
ING3 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간, 생쥐, 랫드 시료에 반응합니다. Western blot 및 IHC(P) 실험에 적합하며, 고순도의 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보존되어 안정적인 신호 검출이 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ING3 (Accession Q9NXR8), corresponding to amino acid residues V273–S323 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852361 |
Product Specific Information
Antibody detects endogenous levels of total ING3.
Target Information
The ING3 protein is similar to ING1, a tumor suppressor protein that interacts with TP53, inhibits cell growth, and induces apoptosis. It contains a PHD-finger motif common in chromatin remodeling proteins and can activate p53 trans-activated promoters such as p21/waf1 and bax. Overexpression of ING3 inhibits cell growth and induces apoptosis. Reduced expression and allelic loss have been observed in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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