Thermo Fisher Scientific Myeloid-Associated Differentiation Marker (MYADM) Monoclonal Antibody (MYADM, 972)
MYADM 단백질을 인식하는 Thermo Fisher의 단클론 항체로, 인간 및 영장류 시료에 반응합니다. IHC, ICC/IF, Flow Cytometry에 적합하며, 단백질 A/G로 정제된 액상 형태입니다. 조혈세포 분화 및 백혈병 연구용으로 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MYADM, 972 |
| Immunogen | Recombinant human MYADM protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA-fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
MYADM, a member of the MAL family, is a 322-amino acid protein with seven hydrophobic transmembrane domains and several potential phosphorylation sites. It shares 75.8% sequence identity with mouse in the transmembrane regions. MYADM is associated with differentiation of hematopoietic cells and acute promyelocytic leukemia cells. Its expression is up-regulated in NB4 cells induced by all-trans retinoic acid, while down-regulation inhibits bone marrow colony formation. MYADM may serve as a marker for hematopoietic differentiation and a potential diagnostic, prognostic, or therapeutic target. It is expressed in brain and pancreatic islet cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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