Thermo Fisher Scientific PD L1 (CD274) Monoclonal Antibody (OTI2C11)
PD-L1(CD274)에 특이적인 mouse monoclonal antibody로, Western blot 및 Flow cytometry에 적합. 인간 시료 반응성, carrier-free 형태로 제공되어 conjugation 실험에 활용 가능. 종양 면역 회피 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Flow Cytometry (Flow)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C11 |
| Immunogen | Full length human recombinant protein of human CD274 (NP_054862) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments with this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a B7 family member that binds to the programmed death receptor 1 (PD-1), negatively regulating T-cell receptor (TCR) signaling.
PD-L1 engagement reduces TCR-mediated proliferation and cytokine production. Its expression is abundant in many murine and human cancers and can be up-regulated upon IFN-γ stimulation, suggesting a key role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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