Thermo Fisher Scientific Phospho-SMAD2 (Ser465, Ser467) Polyclonal Antibody
Phospho-SMAD2 (Ser465, Ser467) 특이적 폴리클로날 항체로, TGF-β 신호전달 연구에 적합. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 사람 및 생쥐 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 4 publications |
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 3 publications |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | View publications |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide encompassing the phosphorylated serine 465 and 467 residues of human, mouse, and rat Smad2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533446 |
Target Information
SMAD2 (MADH2, MAD2) regulates multiple cellular processes such as cell proliferation, apoptosis, and differentiation.
It interacts with TGF-beta receptors via SMAD anchor for receptor activation, leading to nuclear translocation—a central event in TGF-beta signaling.
Phosphorylation of threonine 8 by ERK1 enhances SMAD2 transcriptional activity, while calmodulin negatively regulates it.
Upon TGF-beta stimulation, SMAD2 is phosphorylated by TGF-beta receptors, dissociates from SARA, and associates with SMAD4 for nuclear translocation and transcriptional regulation.
SMAD2 can also be phosphorylated by activin type 1 receptor kinase to mediate activin signaling.
Alternatively spliced transcript variants encoding SMAD2 have been reported.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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