Thermo Fisher Scientific QKI Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water and centrifuge to remove any insoluble material.
Specificity: QKI isoforms 3, 5, 6, 7.

Target Information

This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus.
It is highly expressed in the central nervous system, also found in skin, skeletal muscles, and at low levels in the pancreas.
Mutations in this gene cause autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy.
Sacsin protects against mutant ataxin-1. A pseudogene is located on chromosome 11.
Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.