Thermo Fisher Scientific Human IL-17F, Animal-Free Recombinant Protein, PeproTech
동물 유래 성분이 없는 재조합 인간 IL-17F 단백질로, E.coli에서 발현되어 높은 순도(≥98%)와 낮은 엔도톡신(<0.1 EU/µg)을 보유합니다. IL-6 유도 활성 검증 완료. 염증성 사이토카인 연구 및 세포 활성 분석에 적합합니다.
- 카탈로그번호
- AF-200-25-xxxxx (2개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human IL-17F, Animal-Free Recombinant Protein, PeproTech
Applications
- Functional Assay (Functional): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ |
| Molecular Weight | 30.1 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | < 0.1 EU/µg |
| Activity | Induces IL-6 production by NHDF cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
The mature human IL-17F is a homodimeric protein with a total weight of 30.1 kDa, consisting of two 133 amino acid residue chains.
E. coli-derived Recombinant Human IL-17F is a biologically active, non-glycosylated, disulfide-linked homodimeric protein containing 268 amino acids (30.1 kDa), including N-terminal methionine residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
IL-17F (Interleukin 17F, CTLA-8) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils.
IL-17F is involved in allergic airway inflammation and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils.
It may be secreted as a homodimer or a heterodimer with IL-17A. It acts by binding to the type I receptor IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production.
IL-17F stimulates induction of other pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and IL-8, and is implicated in chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.
TGF-β and IL-23 are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce other pro-inflammatory cytokines.
IL-17F exists as a homodimer, shares homology with a herpes virus early protein, and is one of six members (IL-17A–F) of this cytokine family. It is highly expressed by activated effector memory T cells and has been found to inhibit angiogenesis and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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