Thermo Fisher Scientific HBP1 Polyclonal Antibody
HBP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot에 적합하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 인간 HBP1 내부 영역 유래 합성 펩타이드로 면역화되었으며, 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific HBP1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Publications: - References
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human HBP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555136 |
Target Information
The HMG-box protein-1 (HBP1) is a member of the HMG family of transcription factors, characterized by the presence of a conserved high mobility group (HMG) 1 box that mediates DNA binding. HBP1 binds to tumor suppressor proteins Rb and p130 to initiate cell cycle arrest. Terminal cell differentiation requires this initial arrest followed by coordinated expression of tissue-specific marker genes.
HBP1 activity suppresses expression of tissue-specific genes by associating with MyoD proteins. In muscle cell differentiation, the MyoD family (Myf5, MyoD, myogenein) induces expression of cell-type specific proteins and contributes to phenotype development. Thus, terminal differentiation progression depends on decreased HBP1 activity and activation of MyoD-induced transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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