Thermo Fisher Scientific RNF139 Polyclonal Antibody
Human RNF139 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(Paraffin) 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 기반 용액 형태로 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- PA551534
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RNF139 (Product #RP-96771) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646625 |
Product Specific Information
Immunogen sequence:
PEIKGSRLQE INDVCAICYH EFTTSARITP CNHYFHALCL RKWLYIQDTC PMCHQKVYIE DDIKDNSNVS NNNGFIPPNE TPEEAVREAA AESDRELNED DSTDCDDDVQ RERNGVIQHT GAAAEEF
- Highest antigen sequence identity to orthologs:
- Mouse: 88%
- Rat: 88%
Target Information
The RNF139 protein is a multi-membrane spanning protein containing a RING-H2 finger domain. It is located in the endoplasmic reticulum and exhibits ubiquitin ligase activity. The gene may be disrupted by translocation in families with hereditary renal and non-medullary thyroid cancer. Studies in Drosophila suggest possible interactions with tumor suppressor protein VHL and COPS5/JAB1, involved in degradation of CDKN1B/P27KIP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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