Thermo Fisher Scientific MEK2 Polyclonal Antibody
Rabbit polyclonal antibody against human MEK2, cross-reactive with mouse and rat. Suitable for Western blot (1–3 µg/mL). Supplied as liquid, 0.5 mg/mL. Store at 4°C short term or -20°C long term. For research use only.
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Applications
Western Blot (WB)
- Tested dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Human MEK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_1076639 |
Product Specific Information
This antibody will cross-react with mouse and rat MEK2, based on sequence homology.
Suggested positive control: 293 whole cell lysate.
Target Information
MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that plays a critical role in mitogen growth factor signal transduction.
Mitogen activated protein kinase 2 (MEK2 or MAPKK2) belongs to a family of tyrosine/threonine protein kinases that activate ERK1/2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop.
MEK1 and MEK2 are activated by dual phosphorylation on serine 218 and 222 in the activation loop. Threonine 292 of MEK1 is phosphorylated by ERK2, serving as a negative feedback loop to suppress MEK1 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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