Thermo Fisher Scientific PCID2 Polyclonal Antibody
Thermo Fisher Scientific PCID2 Polyclonal Antibody는 인간 및 생쥐 PCID2 단백질을 검출하는 고품질 항체입니다. Western blot과 IHC(Paraffin) 분석에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. TREX-2 복합체 연구 및 B세포 생존 관련 단백질 분석에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein of human PCID2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636630 |
Product Specific Information
The antibody detects endogenous levels of total PCID2 protein.
Target Information
Required for B-cell survival through regulation of cell-cycle checkpoint MAD2L1 protein expression during B cell differentiation.
Component of the TREX-2 complex (transcription and export complex 2), composed of ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388).
TREX-2 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).
It participates in mRNA export and accurate chromatin positioning by tethering genes to the nuclear periphery.
PCID2 binds and stabilizes BRCA2, contributing to the control of R-loop-associated DNA damage and transcription-associated genomic instability.
R-loop accumulation does not increase in PCID2-depleted cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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