Thermo Fisher Scientific CD122 Polyclonal Antibody

Thermo Fisher Scientific CD122 Polyclonal Antibody

Applications and Tested Dilution

• Application: Western Blot (WB)
• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, HepG2, HCT116
• Predicted reactivity: Rhesus Monkey (97%), Chimpanzee (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and exists in three forms:

1. Low affinity form: Monomer of the alpha subunit; not involved in signal transduction.
2. Intermediate affinity form: Alpha/beta subunit heterodimer.
3. High affinity form: Alpha/beta/gamma subunit heterotrimer.

Both intermediate and high affinity forms participate in receptor-mediated endocytosis and mitogenic signal transduction.
The CD122 gene encodes the beta subunit, a type I membrane protein.
Dysfunction of CD122 is associated with diseases such as oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.