Thermo Fisher Scientific RuvBL2 Polyclonal Antibody
Thermo Fisher Scientific의 RuvBL2 Polyclonal Antibody는 인간 RuvB-like 2 단백질을 인식하는 토끼 유래 항체입니다. Western blot 및 Immunoprecipitation에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 5–15 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 413 and 463 of Human RuvB-like 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Bovine.
Target Information
RUVBL2 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′ to 3′) activity. It is a component of the NuA4 histone acetyltransferase complex involved in transcriptional activation of select genes via acetylation of nucleosomal histones H4 and H2A. This modification can alter nucleosome–DNA interactions and promote association with other transcription-regulating proteins.
The NuA4 complex contributes to transcriptional programs related to oncogene-induced growth, tumor suppressor-mediated arrest, senescence, apoptosis, and DNA repair. RUVBL2, in association with RUVBL1 and EP400, plays a critical role in these processes and in oncogenic transformation by MYC as well as transcriptional modulation by the LEF1/TCF1-CTNNB1 complex. It may also inhibit ATF2 transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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