Thermo Fisher Scientific RuvBL2 Polyclonal Antibody
RuvBL2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 인간 및 마우스 반응성. 연구용으로만 사용 가능.
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Applications and Recommended Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 5–15 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human RuvB-like 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC (FFPE sections), epitope retrieval with citrate buffer (pH 6.0) is recommended
- Based on 100% sequence identity, antibody is predicted to react with Bovine
Target Information
RUVBL2 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′ to 3′) activity. It is a component of the NuA4 histone acetyltransferase complex involved in transcriptional activation of select genes through histone acetylation (H4 and H2A). This modification alters nucleosome–DNA interactions and promotes recruitment of transcription-regulating proteins. The NuA4 complex is implicated in oncogene- and proto-oncogene-mediated growth induction, tumor suppressor-mediated growth arrest, replicative senescence, apoptosis, and DNA repair. RUVBL2, together with RUVBL1 and EP400, contributes to the ATPase and helicase activities of NuA4 and plays a direct role in DNA repair. It is essential for MYC-mediated oncogenic transformation and modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. RUVBL2 may also inhibit the transcriptional activity of ATF2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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