Thermo Fisher Scientific ERBB3 Monoclonal Antibody (OTI1B11), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. It is over-expressed in various tumors including prostate, bladder, breast, stomach, pancreas, and colon.
Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on chromosome 12q13, producing a 6.2 kb mRNA translated into a 160/180 kDa glycoprotein.
ErbB3 forms heterodimers with other EGF receptor family members, activating pathways for cell proliferation and differentiation.
Alternate splice variants exist, including secreted forms that modulate membrane-bound receptor activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.