Thermo Fisher Scientific KAL1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human KAL1 (Anosmin-1), validated for WB and ICC/IF. Detects endogenous KAL1 levels. Supplied as liquid, 1 mg/mL, purified by affinity chromatography. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ANOS1 (Accession P23352), corresponding to amino acid residues K162–I212 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850864 |
Product Specific Information
Antibody detects endogenous levels of total KAL1.
Target Information
KAL1 (Anosmin-1) is an extracellular matrix-associated glycosylated protein linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell due to abnormal olfactory bulb development and delayed puberty caused by disrupted migration of gonadotropin-releasing hormone neurons.
Anosmin-1 binds FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought to modulate FGFR1 signaling and influence FGF2-FGFR1-heparin complex formation and activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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