Thermo Fisher Scientific Phospho-CD244 (Tyr271) Polyclonal Antibody
인간 CD244 인산화 부위(Tyr271)를 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 사용 가능. Protein A로 정제된 액상형 항체이며, 안정적인 저장용 버퍼를 포함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human CD244 around the phosphorylation site of Tyr271 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells and some T cells that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK cells and target cells via CD244 modulates NK-cell cytolytic activity. CD244 interacts with SLAMF2, activating both SLAMF4- and SLAMF2-expressing cells. Reduced SLAMF4 expression on NK cells and monocytes has been observed in patients with systemic lupus erythematosus, suggesting a role in autoimmune pathology. CD244 dysfunction is associated with rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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