Thermo Fisher Scientific Metadherin Polyclonal Antibody
Metadherin 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성 보유. 항원 친화 크로마토그래피로 정제된 액상 제품으로 장기 보관 시 -20°C 권장.
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Applications
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human LYRIC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.69 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792245 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (91%), Rat (91%), Pig (93%), Rhesus Monkey (98%), Bovine (94%).
- Positive Control: Rat brain.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, is a novel protein that localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It is recruited during tight junction maturation and not a structural component. Metadherin is overexpressed in breast cancer tissue and xenografts, with lower expression in normal breast tissue. It binds to lung vasculature, a common site of breast cancer metastasis, through a C-terminal extracellular domain segment. Blocking this domain or inhibiting Metadherin with siRNA has been reported to suppress breast cancer metastasis.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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