Thermo Fisher Scientific RASIP1 Polyclonal Antibody
RASIP1 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 혈관 형성 및 GTPase 신호 조절 연구에 활용 가능합니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human RASIP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719526 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
RASIP1 is required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. It acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which are essential for endothelial cell morphogenesis and blood vessel tubulogenesis.
It regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling, thereby dampening ROCK and MYH9 activities in endothelial cells.
RASIP1 may act as an effector for Golgi-bound HRAS and other Ras-like proteins and may promote HRAS-mediated transformation. It also serves as a negative regulator of amino acid starvation-induced autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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