Thermo Fisher Scientific Human PLEKHM3 Synthetic Peptide

Thermo Fisher Scientific Human PLEKHM3 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 13 amino acids near the carboxy terminus of human PLEKHM3.
PEP-0965 can be used as a blocking peptide with polyclonal antibody PA5-20851.

Target Information

PLEKHM3, also known as DAPR, is a member of the M family of Pleckstrin homology domain-containing proteins.
PLEKHM3 was initially identified through chromatin immunoprecipitation and CpG microarray analysis examining proteins regulated by myocyte-enhancing factor 2.

In C2C12 myoblast cells, PLEKHM3 binds to the PI3K signaling member protein kinase B in the cytosol prior to differentiation into myotubes.
Following the initiation of differentiation, PLEKHM3 was also found in membrane fractions.
Knockdown of PLEKHM3 expression by RNAi resulted in inhibition of myotube formation, suggesting that PLEKHM3 is a key component required by myoblasts for orchestrating their differentiation during myogenesis.

Usage Note

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.