Thermo Fisher Scientific VEGF Receptor 1 (Flt1) Monoclonal Antibody (Flt-19), eBioscience

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

Assay-Dependent

-

ELISA (ELISA)

Assay-Dependent

-

Immunoprecipitation (IP)

Assay-Dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

Flt-19

Immunogen

Rec. Human VEGF-R1 (FLT-1)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

purified

Storage buffer

tissue culture supernatant with 10% FBS

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_10596506

Product Specific Information

Description: BMS196 reacts specifically with the extracellular domain of human VEGF Receptor-1. The epitope recognized by BMS196 resides within a.a. residues 1-251 of the VEGF-R1. The antibody does not recognize VEGF-R2.

Applications Tested: ELISA, Immunohistochemistry, Immunoprecipitation.

Target Information

FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.