Thermo Fisher Scientific LPIN1 Monoclonal Antibody (OTI4C11), TrueMAB
인간 LPIN1 단백질을 인식하는 Mouse monoclonal 항체로, IHC(P)에서 1:150 희석 비율로 검증됨. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol buffer에 보관. 지방 대사 및 인슐린 감수성 연구에 적합한 연구용 항체.
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Applications
Tested Applications and Dilution
- Immunohistochemistry (Paraffin) (IHC-P): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–274 of human LPIN1 produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, all containing a nuclear localization signal, a conserved N-terminal (NLIP) domain, and a C-terminal (CLIP) domain.
LPIN1 (Lipin-1) is essential for normal adipose tissue development and metabolism. It activates PGC-1A target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation, by inducing expression of the nuclear receptor PPARA.
LPIN1 also suppresses lipogenesis and circulating lipid levels. Overexpression promotes fat accumulation and insulin sensitivity, while deficiency can lead to lipodystrophy, fatty liver, hypertriglyceridemia, and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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