Thermo Fisher Scientific ANGPT2 Monoclonal Antibody (OTI4A3), TrueMAB
Human ANGPT2 단백질(aa 19-496)을 항원으로 제작된 mouse IgG1 monoclonal antibody. Western blot에 1:2,000 희석으로 사용 가능. 액상 형태로 1 mg/mL 농도이며, PBS/BSA/glycerol buffer에 보관. -20°C에서 냉동 보관하며 반복 동결/해동은 피해야 함.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19–496 of human ANGPT2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2, but unlike ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and can act as either an agonist or antagonist of Tie-2–induced angiogenesis depending on the physiological environment.
The signaling interactions of ANG-1, ANG-2, and Tie-2, along with less characterized ANG-3 and ANG-4, are essential for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acid residues, composed of an alpha-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain. ANG-2 predominantly exists as a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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