Thermo Fisher Scientific IRF3 Monoclonal Antibody (OTI4A1), TrueMAB
IRF3 단백질을 인식하는 Mouse Monoclonal Antibody로, Western blot, IHC, ICC 등 다양한 응용에 사용 가능. 동결건조 형태로 제공되며, PBS 버퍼와 trehalose가 포함됨. 인간 단백질에 반응하며, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 27–169 of human IRF3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses.
It plays a critical role in the innate immune response against DNA and RNA viruses by regulating transcription of type I IFN genes (IFN-α, IFN-β) and IFN-stimulated genes (ISG) through binding to interferon-stimulated response elements (ISRE).
IRF3 is activated via phosphorylation by IKBKE and TBK1, leading to dimerization, nuclear translocation, and activation of IFN gene transcription.
Mutations in the IRF3 gene can cause acute encephalopathy associated with herpesvirus infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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