Thermo Fisher Scientific NCOA2 Monoclonal Antibody (OTI3C7), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Target Information

SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2 or TIF2), aids in the function of nuclear hormone receptors. These receptors are conditional transcription factors that regulate gene expression involved in cell growth, development, and homeostasis.
Members of the nuclear hormone receptor superfamily include steroid receptors and class II nuclear receptors, characterized by three domains:

1. N-terminal transcriptional activation domain
2. Central DNA-binding domain
3. C-terminal hormone-binding domain

Before hormone binding, steroid receptors remain inactive in a complex with heat-shock protein-90 and other stress-related proteins. Hormone binding induces conformational changes, leading to dissociation from the inhibitory complex and homodimer binding to specific DNA enhancer elements. These transcription factors then require coactivator proteins, such as SRC2/NCOA2, to stimulate transcription initiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.