Thermo Fisher Scientific HCN2 Polyclonal Antibody
HCN2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. Mouse와 Rat에 반응하며, 합성 펩타이드 면역원으로 제작되었습니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse HCN2 conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat.
- Specificity of this antibody: HCN2.
Target Information
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.
HCN2 is part of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides.
HCN1 and HCN2 play important roles in motor learning and neuronal integration by cerebellar Purkinje cells, shaping autonomous neuronal activity and network oscillations.
HCN1 is enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus, whereas HCN2 is abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body.
These regional variations in HCN channel expression contribute to differences in neuronal pacemaker activity across brain systems.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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