Thermo Fisher Scientific CD200 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 30-240 of human CD200 (NP_0059354) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD200,uniProtId:P41217-1,ncbiNodeId:9606,antigenRange:30-240,antigenLength:278,antigenImageFileName:PA5-93052_CD200_P41217-1_Rabbit.svg,antigenImageFileNamePDP:PA5-93052_CD200_P41217-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.51 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806605

Product Specific Information

Immunogen sequence: AQVQVVTQDE REQLYTPASL KCSLQNAQEA LIVTWQKKKA VSPENMVTFS ENHGVVIQPA YKDKINITQL GLQNSTITFW NITLEDEGCY MCLFNTFGFG KISGTACLTV YVQPIVSLHY KFSEDHLNIT CSATARPAPM VFWKVPRSGI ENSTVTLSHP NGTTSVTSIL HIKDPKNQVG KEVICQVLHL GTVTDFKQTV NKGYWFSVPL L; Positive Samples: Mouse brain, Mouse heart, Rat brain; Cellular Location: Cell membrane, Single-pass type I membrane protein

Target Information

CD200 is a type-1 membrane glycoprotein that contains two immunoglobulin domains, and belongs to the immunoglobulin superfamily. CD200 is a broadly distributed cell surface glycoprotein that interacts with a receptor on myeloid cells (CD200R) and is implicated in locally preventing macrophage activation. Distant, but recognizable, homologues of CD200 have been identified in many herpesviruses and poxviruses. Studies of the related genes in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms of CD200 have been found. Diseases associated with CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.