Thermo Fisher Scientific CD53 Polyclonal Antibody
Rabbit polyclonal antibody against human CD53 for IHC (paraffin) applications. Recognizes recombinant human CD53 protein. Supplied as liquid, unconjugated form with 0.05 mg/mL concentration. Suitable for research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC-P): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CD53. Recombinant protein control fragment (Product # RP-91155) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791013 |
Product Specific Information
Immunogen sequence:
NEYVAKGLTD SIHRYHSDNS TKAAWDSIQS FLQCCGINGT SDWTSGPPAS CPSDRKVEGC YAKARLWFHS
Target Information
CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. It forms complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4, or tetraspanins CD37, CD81, and CD82, modulating various signaling processes. CD53 is involved in radioresistance of tumor cells and exhibits anti-apoptotic effects. In the thymus, CD53 is upregulated in response to positive selection signals during T cell development and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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