Thermo Fisher Scientific RNF17 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human RNF17. Recombinant protein control fragment (Product #RP-97953). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RNF17,uniProtId:Q9BXT8-3,ncbiNodeId:9606,antigenRange:864-962,antigenLength:1623,antigenImageFileName:PA5-58889_RNF17_Q9BXT8-3_Rabbit.svg,antigenImageFileNamePDP:PA5-58889_RNF17_Q9BXT8-3_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646641

Product Specific Information

Immunogen sequence: SYEIGYILKD NSQKHIEVWD PSPEEIISNE VHNLNPVSAK SLPNENFQSL YNKELPVHIC NVISPEKIYV QWLLTENLLN SLEEKMIAAY ENSKWEPVK

Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 79%.

Target Information

RNF17 also termed as ring finger protein 17 is a 1623 amino acid protein, which contains 1 ring type zinc finger and 4 tudor domains. RNF17 is specifically expressed in testis. The RING finger motif presents in many ubiquitin E3 ligases. RNF17 interacts with all four members of the Mad family (Mad1, Mxi1, Mad3 and Mad4), which are basic-helix-loop-helix-leucine zipper transcription factors of the Myc oncoprotein network. RNF17 is component of the tectonic-like complex, which is required for ciliogenesis and sonic hedgehog/SHH signaling. RNF17 is able to form dimers or polymers both in vitro and in vivo, indicating that it may play a role in the assembly of RNF17 granules. RNF17 encodes a novel key regulator of spermiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.