Thermo Fisher Scientific PDE8A Polyclonal Antibody
Thermo Fisher Scientific의 PDE8A Polyclonal Antibody는 Mouse 및 Rat 시료에서 PDE8A 단백질 검출에 사용됩니다. Western blot과 ELISA에 적합하며, 고순도의 Rabbit IgG 폴리클로날 항체입니다. 액상 형태로 제공되며, PBS/glycerol buffer에 보관됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–120 of human PDE8A (NP_002596.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.6 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804888 |
Product Specific Information
Immunogen sequence:
MGCAPSIHIS ERLVAEDAPS PAAPPLSSGG PRLPQGQKTA ALPRTRGAGL LESELRDGSG KKVAVADVQF GPMRFHQDQL QVLLVFTKED NQCNGFCRAC EKAGFKCTVT KEAQAVLACF
Positive Samples:
Mouse testis, Mouse eye, Mouse liver, Rat testis
Target Information
Phosphodiesterases (PDEs) regulate intracellular levels of cAMP and cGMP. These cyclic nucleotides act as second messengers in multiple physiological processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs form a large superfamily divided into 10 families, distinguishable by structure, tissue expression, localization, substrate specificity, regulation, and inhibitor sensitivity. Their structural and functional diversity makes PDEs promising targets for pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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