Thermo Fisher Scientific GITR/Tnfrsf18 Monoclonal Antibody (DTA-1)
마우스 GITR/TNFRSF18 단백질을 인식하는 Rat IgG2b 단일클론 항체로, ICC/IF 및 유세포분석에 적합합니다. 단백질 A/G로 정제된 액상형 비결합 항체이며, PBS(pH 7.4)에 보존제 없이 저장됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2b, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DTA-1 |
| Immunogen | Mouse CD25⁺ CD4⁺ T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is encoded by the TNFRSF18 gene in humans and mapped to chromosome 1p36.33. This receptor belongs to the TNF-receptor superfamily and is upregulated upon T-cell activation. It plays a key role in maintaining immunological self-tolerance mediated by CD25⁺CD4⁺ regulatory T cells. Knockout studies in mice indicate its involvement in CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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