Thermo Fisher Scientific STAT6 Polyclonal Antibody
STAT6 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 사용 가능. IL-4 및 IL-13 신호전달 관련 연구에 적합하며, 4°C에서 보관. 액상 형태로 제공되며 권장 농도는 1 mg/mL.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600 and 650 of Human Signal Transducer and Activator of Transcription 6 (STAT6, UniProt ID: P42226-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 (IL-4) and IL-13. STAT6-deficient (Stat6−/−) models show impaired IL-4-mediated functions, including Th2 helper T-cell differentiation, expression of surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and reduced IL-4-induced proliferation.
STAT6 mRNA is expressed in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.
STAT6 plays a critical role in Th2 immune response and IL-4-mediated biological processes. It exists in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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