Thermo Fisher Scientific CRX1 Polyclonal Antibody
CRX 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트에 반응하며 Protein A로 정제되었습니다. 고농도(1 mg/mL) 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human CRX (amino acids 51–150) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes. It is also expressed in pinealocytes of the pineal gland, potentially regulating circadian activity via melatonin synthesis gene expression. Mutations in the CRX gene are associated with cone-rod dystrophy (CORD), Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP). The human CRX gene is located on chromosome 19q13.3 within the CORD2 locus.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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