Thermo Fisher Scientific BRUCE Polyclonal Antibody
인간 BRUCE 단백질을 인식하는 Rabbit Polyclonal 항체로, 세포면역형광(ICC/IF)에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 0.2 mg/mL 농도의 액상 형태로 제공. 세포사멸 연구 및 IAP 단백질 관련 연구에 적합.
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Applications and Tested Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human BRUCE. Recombinant protein control fragment (Product #RP-108015) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664898 |
Product Specific Information
Immunogen sequence:
GSTDNESCTNS ELNSPLVRRT LPVLLLYSIK ESDEKAGKIF SQMNNIMSKS LHDDGFTVPQ IIEMELDSQE QLLLQDPPVT YIQQFADAA
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
Apoptosis (programmed cell death) is associated with various diseases, including cancer. It is triggered by stimuli such as TNF family members and can be inhibited by IAP (inhibitor of apoptosis) proteins.
BRUCE, also known as BIRC6, is a member of the IAP family containing both BIR (baculoviral inhibition of apoptosis protein repeat) and UBCc (ubiquitin-conjugating enzyme E2 catalytic) domains.
BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the ubiquitination and degradation of apoptotic proteins such as Caspase-9 and SMAC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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