Thermo Fisher Scientific RAB8A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.3 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with bovine and canine based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 32,000.

Target Information

The protein encoded by this gene is a member of the RAS superfamily, which includes small GTP/GDP-binding proteins (~200 amino acids). RAB/YPT family proteins may play a role in transporting proteins from the endoplasmic reticulum to the Golgi and plasma membrane.
This protein shares 97%, 96%, and 51% similarity with dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively, and contains four GTP/GDP-binding sites typical of RAS proteins.
It also includes a C-terminal CAAX motif characteristic of RAS superfamily members but absent in YPT1 and most RAB proteins. Although isolated as a transforming gene from a melanoma cell line, no link between MEL and malignant melanoma has been demonstrated.
This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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