Thermo Fisher Scientific SOX2 Monoclonal Antibody (GT1876)
SOX2 단백질을 인식하는 단클론 항체로, Western blot, IHC, ICC, Flow cytometry, IP 등에 사용 가능. 인간, 마우스, 랫트, 제브라피시 등 다양한 종에 반응. 단백질 G로 정제된 액상 항체로, 줄기세포 연구 및 발달 생물학 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:10,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT1876 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human SOX2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787087 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (92%), Japanese Medaka (88%), Xenopus laevis (90%), Cat (100%), Pig (98%), Chicken (94%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%).
- Positive Control: NT2D1, PC-3, U87-MG, SK-N-SH, human ESC, zebrafish eye.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate.
The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach.
The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins.
Mutations in the SOX2 gene have been associated with bilateral anophthalmia, optic nerve hypoplasia, and syndromic microphthalmia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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