Thermo Fisher Scientific 4-1BBL/CD137L/TNFSF9 Recombinant Rabbit Monoclonal Antibody (BLR148J)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Flow Cytometry (Flow)

0.5 µL/10^6 cells

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

BLR148J

Immunogen

Recombinant protein representing the extracellular domain of Human Tumor necrosis factor ligand superfamily member 9 (TNFSF9, aka 4-1BBL, CD137L; residues 71-254). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:4-1BBL (CD137L),uniProtId:P41273-1,ncbiNodeId:9606,antigenRange:71-254,antigenLength:254,antigenImageFileName:A700-148_4-1BBL_CD137L_P41273-1_Rabbit.svg,antigenImageFileNamePDP:A700-148_4-1BBL_CD137L_P41273-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

purified

Storage buffer

PBS, pH 6.8 to 7.4

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.