Thermo Fisher Scientific STAT6 Recombinant Rabbit Monoclonal Antibody (BLR147J)
STAT6 단백질을 인식하는 Recombinant Rabbit Monoclonal 항체로, Western blot, IHC, ICC/IF, IP에 사용 가능. Human 및 Mouse 반응성. HEK293F 발현 시스템, 비결합형 액상 포맷. 4°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 20 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR147J |
| Immunogen | Peptide representing a region between residue 600 and 650 of Human Signal Transducer and Activator of Transcription 6 (STAT6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 300 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 (IL-4) and IL-13. STAT6-deficient (Stat6-/-) models show impaired IL-4-mediated functions such as Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4-mediated proliferation.
STAT6 mRNA is detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. STAT6 plays a critical role in Th2 immune responses and IL-4-mediated biological processes, existing naturally in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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