Thermo Fisher Scientific CD100 Recombinant Human Monoclonal Antibody (5D12)
CD100(Recombinant Human Monoclonal Antibody, Clone 5D12)은 인간 및 마우스 반응성을 가지며, Flow Cytometry와 ELISA에 사용 가능합니다. HEK293 세포에서 발현된 IgG4 형 항체로, 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 버퍼에 보관됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Human / IgG4 |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5D12 |
| Immunogen | Recombinant Human SEMA4D protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3093855 |
Target Information
Semaphorins are neuronal chemorepellants that guide pioneering neurons during nervous system development.
CD100 (also known as Semaphorin 4D), a 150 kDa homodimer, is a semaphorin that induces B cell aggregation and enhances their viability in vitro.
CD100 modifies CD40-CD40L B cell signaling by promoting aggregation and survival while downregulating CD23 expression.
CD72 acts as a lymphocyte receptor for CD100, regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and more strongly on activated T and B cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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