Thermo Fisher Scientific Human CDK7/Cyclin H/MNAT1, His Tag Recombinant Protein
Human CDK7/Cyclin H/MNAT1 삼중 복합체 재조합 단백질로, Cdk 활성화 키나아제(CAK) 기능을 수행합니다. Insect cell에서 발현된 His-tag 단백질이며, SDS-PAGE 기준 70% 순도입니다. 전사 개시 및 DNA 복구 연구용으로 사용되며, -80°C 보관이 권장됩니다.
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Applications
- Kinase Assay (KA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | Full length |
| Tag | His-tag |
| Molecular Weight | 43.2–42.6–40.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | 70% by SDS-PAGE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris, pH 7.5, with 2 mM DTT, 50% glycerol, 0.02% Triton X-100, 150 mM NaCl, 0.5 mM EDTA |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
For maximum recovery, please spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
For larger sizes, reduce freeze/thaw cycles by preparing aliquots (not below 20 µL).
Do not store kinase diluted.
Properly stored at -80°C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Recombinant, Full Length
Target Information
The trimeric complex of CDK7, Cyclin H, and MNAT1 functions as a Cdk-activating kinase (CAK).
It is an essential component of transcription factor TFIIH, involved in transcription initiation and DNA repair.
This complex serves as a direct link between transcription regulation and the cell cycle.
It plays a role in BRCA1-associated double-strand break repair.
CDK7 may be a target of germline cancer-inducing mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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