Thermo Fisher Scientific Human CDK9/Cyclin T1, His Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
• For larger sizes, aliquots may be prepared to reduce freeze/thaw cycles (avoid aliquots below 20 µL).
• Do not store kinase diluted.
• Properly stored at -80°C, guaranteed for 6 months from date of purchase.

Protein Form: Recombinant, Full Length

Target Information

CDK9 is a serine/threonine kinase that forms an active holoenzyme complex with Cyclin T1, regulating the eukaryotic cell cycle. Coexpressed and copurified with Cyclin T1, CDK9 facilitates promoter recognition of transcription factors and promotes RNA synthesis involved in cell growth, differentiation, and viral pathogenesis. The CDK9/Cyclin-K complex exhibits kinase activity toward CTD of RNAPII and can substitute for CDK9/Cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement, leading to cardiac hypertrophy and predisposition to heart failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.