Thermo Fisher Scientific CALHM1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1.0 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Immunogen sequence: GITDQGTMNR LLTSWHKCKP PLRLGQEAPL MSNGWAGGEP RPPRKEVATY (aa 295-344). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CALHM1,uniProtId:D3Z291-1,ncbiNodeId:10090,antigenRange:295-344,antigenLength:348,antigenImageFileName:PA5-113789_CALHM1_D3Z291-1_Rabbit.svg,antigenImageFileNamePDP:PA5-113789_CALHM1_D3Z291-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2884304

Product Specific Information

Immunogen sequence: GITDQGTMNR LLTSWHKCKP PLRLGQEAPL MSNGWAGGEP RPPRKEVATY

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Predicted homology: Cow: 93%; Dog: 93%; Horse: 85%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 93%; Rat: 100%

Target Information

Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.