Thermo Fisher Scientific TPP1 Monoclonal Antibody (3B1)
TPP1 단백질을 인식하는 Mouse monoclonal antibody (Clone 3B1). Western blot, IHC, ELISA에 사용 가능. 인간 시료에 반응하며, PBS buffer 내 액상 형태로 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B1 |
| Immunogen | TPP1 (AAH14863, 195 a.a. – approximately 304 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GLHLGVTPSV IRKRYNLTSQ DVGSGTSNNS QACAQFLEQY FHDSDLAQFM RLFGGNFAHQ ASVARVVGQQ GRGRAGIEAS LDVQYLMSAG ANISTWVYSS PGRHEGQEPF
Target Information
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates and has weaker endopeptidase activity. It is synthesized as a catalytically inactive enzyme, which is activated and auto-proteolyzed upon acidification.
Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, associated with failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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