Thermo Fisher Scientific TPP1 Monoclonal Antibody (3B1)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-Dependent

-

Immunohistochemistry (Paraffin) (IHC (P))

3 µg/mL

-

ELISA (ELISA)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

3B1

Immunogen

TPP1 (AAH14863.1, 195 a.a. approximately 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CLN2,uniProtId:O14773-1,ncbiNodeId:9606,antigenRange:195-304,antigenLength:563,antigenImageFileName:H00001200-M01J_CLN2_O14773-1_House_mouse.svg,antigenImageFileNamePDP:H00001200-M01J_CLN2_O14773-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: GLHLGVTPSV IRKRYNLTSQ DVGSGTSNNS QACAQFLEQY FHDSDLAQFM RLFGGNFAHQ ASVARVVGQQ GRGRAGIEAS LDVQYLMSAG ANISTWVYSS PGRHEGQEPF

Target Information

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.