Thermo Fisher Scientific TRIP12 Polyclonal Antibody
TRIP12 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 항체로, 인간·마우스·랫트 반응성. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TRIP12 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
| Immunoprecipitation (IP) | – |
Publications
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Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 18 amino acid peptide near the carboxy terminus of human TRIP12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2554620 |
Product Specific Information
- Recommended positive control: rat colon tissue lysate
- At least four isoforms are known to exist.
Target Information
TRIP12 is an E3 ubiquitin-protein ligase involved in the ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair.
It mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a tumor suppressor required for p53/TP53 activation under oncogenic stress.
In cancer cells, TRIP12 and p19ARF/ARF are located in different compartments, preventing degradation.
TRIP12 also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation.
Acts as a key regulator of DNA damage response by suppressing RNF168, preventing excessive accumulation of ubiquitinated chromatin at damaged chromosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-38016_TRIP12_Q14669-1_Rabbit.svg, PA5-38016_TRIP12_Q14669-1_Rabbit_PDP.jpeg)
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