Thermo Fisher Scientific PRL1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

Target Information

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif.
PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes.
This tyrosine phosphatase is a nuclear protein, but may primarily associate with the plasma membrane.
The surface membrane association of this protein depends on its C-terminal prenylation.
Overexpression of this gene in mammalian cells confers a transformed phenotype, implicating its role in tumorigenesis.
Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.
PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase.
PRL-1 function is regulated in a cell cycle-dependent manner and may regulate progression through mitosis, possibly by modulating spindle dynamics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.